Correction: Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment
نویسندگان
چکیده
There was an error published in J. Cell Sci. 127, 4531-4541. Incorrect concentrations of the components used to establish the oxidising redox potential were given in the ‘Redox buffering’ section of the Materials and Methods. The correct sentence should read: An oxidising redox potential of −180 mV was established with 0.95 mM GSH and 0.1 mM GSSG. The authors apologise to the readers for any confusion that this error might have caused.
منابع مشابه
Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment
Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in luminal [Ca(2+)]. Basal leak from the sarcoplasmic reticulum is required for normal Ca(2+) handling, but excess diastolic Ca(2+) leak attributed to oxidative stress is thought to lower the threshold of RyR2 for spontaneous sarcoplasmic reticul...
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